Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of Spillage / Water Pans SMADs 1/5/8.SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and targeting ALK3 for ubiquitin-mediated degradation.Here, we identify a deubiqui
Patients with atherosclerotic disease remain at increased risk of future events despite receiving optimal medical treatment.This residual risk is widely heterogeneous, but lipoprotein particles and their content play a major role in determining future cardiovascular events.Beyond low-density lipoprotein cholesterol (LDL-c), other lipoprotein partic
IntroductionThe mesh-based repair of abdominal wall hernias is a commonly employed approach as it is easy to implement and associated with low rates of hernia recurrence.However, the occurrence of hernia mesh infections following such repair can be extremely serious, and no clinical consensus regarding the optimal treatment of such infections has b
This paper quantitatively reveals the meaning of structural breaks for risk management by analyzing US and major European banking sector stocks.Applying newly extended Glosten-Jagannathan-Runkle generalized autoregressive conditional heteroscedasticity models, we supply the following new evidence.First, we find that incorporating structural breaks
Background.The work is devoted to the problem of evaluating the effectiveness of extinguishing open fires of solid combustible substances and materials, as well as internal (closed) fires (if it is impossible to ensure the sealing of the protected volume) by gas fire extinguishing installations when using gas extinguishing agents with special physi